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Interleukin-1 Signaling - Ontify
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Interleukin-1 Signaling
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9020702).
Statements about
Interleukin-1 Signaling
Has Part(s)
37 items
TAK1-Dependent IKK and NF-Kappa-B Activation
MAP3K8 (TPL2)-Dependent MAPK1/3 Activation
NFKB1:RELA Translocates From the Cytosol to the Nucleus
Activated TAK1 Mediates Phosphorylation of the IKK Complex
TAK1 Phosphorylates MKK6
IL1B,Myr82K-Myr83K-IL1A:IL1R1
Interleukin-1 Receptor Type 2 Binds Interleukin 1
IL1 Receptor Antagonist Protein Binds Interleukin 1 Receptors
Interleukin-1 Receptor Type 1: Interleukin 1 Binds Interleukin-1 Receptor Accessory Protein, Membrane Associated Isoform
IL1R1:IL1:IL1RAP Binds MYD88 Homodimer
IL1R1:IL1:IL1RAP:MYD88 Homodimer Binds IRAK4
The Interleukin 1 Receptor Complex Binds Tollip
IRAK4 Is Activated by Autophosphorylation
IRAK2 Is Phosphorylated Downstream of IRAK4 Following IL1 Receptor Activation
IRAK1 Binds to MYD88 Within the IL1R Complex
IRAK4 Phosphorylates IRAK1
IRAK4-Activated IRAK1 Autophosphorylates
Hyperphosphorylated IRAK1 Associates with TRAF6
P62:MEKK3 Binds to TRAF6
TRAF6 Binding Leads to IRAK1:TRAF6 Release
IRAK1 Induces Oligomerisation of TRAF6
Hp-IRAK1:3xTRAF6 Binds UBE2N:UBE2V1:K63-polyUb
TRAF6 Is K63 Poly-Ubiquitinated
UBE2N:UBE2V1 Dissociates From Hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1
Polyubiquitinated TRAF6 Binds the TAK1 Complex
TAK1 Is Activated Within the TAK1 Complex
Hp-IRAK1,hp-IRAK4 Bind Pellino1,2,3
Hp-IRAK1, Hp-IRAK4 4 Phosphorylate Pellino-1 and 2.
Hp-IRAK1:p-Pellino, IRAK4:p-Pellino Bind UBE2N:UBE2V1
Pellino Ubiquitinates IRAK1
K63polyUb-IRAK1 Dissociates
NEMO Binds Polyubiquitinated IRAK1
IKBA Is Phosphorylated by Phospho IKKB Kinase
SCF Beta-TrCP Complex Binds to NFKB P50:p65: Phospho IKBA Complex
Beta-TrCP Ubiquitinates NFKB P50:p65:phospho IKBA Complex
Ubiquitinated and Phosphorylated IKBA Binds to and Is Degraded by the Proteasome Complex
IL1R1 Binds IL1R1 Inhibitors
Instance Of
Biological Pathway
Interleukin-1-Mediated Signaling Pathway
Exact Match
https://identifiers.org/reactome:R-H ...
Part Of
Interleukin-1 Family Signaling
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