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MAP3K8 (TPL2)-Dependent MAPK1/3 Activation - Ontify

MAP3K8 (TPL2)-Dependent MAPK1/3 Activation

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5684264).

Statements about MAP3K8 (TPL2)-Dependent MAPK1/3 Activation

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Instance Of

Biological Pathway

Part Of

MAP Kinase Activation

Interleukin-1 Signaling

Has Part(s)

NFKB P105, TPL2 (COT) and ABIN2 Form a Stable Complex

IKBKB Phosphorylates TPL2 (MAP3K8) at Ser400

MAP3K8 Is Phosphorylated

IKBKB Phosphorylates NFkB P105 Within the NFkB P105:TPL2:ABIN2 Complex

SCF betaTrCP1,2 Binds P-NFkB P105:TPL2:ABIN2

SCF betaTrCP Ubiquitinates NFKB P105 Within P-S927, S932-NFkB P105:TPL2:ABIN2

3xUb,p-S-NFkB P105:TPL2:ABIN2 Dissociates Due to Degradation of P105

TPL2 Phosphorylates MEK1, SEK1

Exact Match

https://identifiers.org/reactome:R-H ...