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P-S990,Ac-K1249-BRIP1 [Nucleoplasm] - Ontify

P-S990,Ac-K1249-BRIP1 [Nucleoplasm]

Instance of entity with accessioned sequence in Homo sapiens with Reactome ID (R-HSA-5687710).

Statements about P-S990,Ac-K1249-BRIP1 [Nucleoplasm]

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Subclass Of

BRCA1 Interacting Protein C-Terminal Helicase 1

Has Part(s)

N6-Acetyllysine

O-Phospho-L-Serine

Exact Match

https://identifiers.org/reactome:R-H ...

Part Of

18 items

ERCC1:XPF Cleaves Flaps Generated by SSA

EXO1 or DNA2 in Complex with BLM or WRN Binds Initially Resected DNA DSBs Along with BRIP1 Recruitment

Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C Complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [Nucleoplasm]

ATR:ATRIP:p-RPA:3' Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [Nucleoplasm]

Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C Complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [Nucleoplasm]

BLM Mediates Dissolution of Double Holliday Junction

Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C Complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [Nucleoplasm]

3' Short Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [Nucleoplasm]

ATR:ATRIP:p-RPA:DNA DSBs with Annealed 3' SsDNA Overhangs and Displaced Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [Nucleoplasm]

3' Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [Nucleoplasm]

3' Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [Nucleoplasm]

D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C Complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [Nucleoplasm]

Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C Complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [Nucleoplasm]

Resolution of Holliday Junctions Cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)

ATR:ATRIP:p-RPA:3' Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [Nucleoplasm]

D-Loop Dissociation and Strand Annealing

3' Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 Mutants (PALB2 Binding):SEM1 [Nucleoplasm]

Defective 3' Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [Nucleoplasm]

:1249

:990