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MyD88:MAL(TIRAP) Cascade Initiated on Plasma Membrane - Ontify
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MyD88:MAL(TIRAP) Cascade Initiated on Plasma Membrane
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-166058).
Statements about
MyD88:MAL(TIRAP) Cascade Initiated on Plasma Membrane
Has Part(s)
22 items
TAK1-Dependent IKK and NF-Kappa-B Activation
IRAK2 Mediated Activation of TAK1 Complex
MAP Kinase Activation
TRAF6 Binds MEKK1
Instance Of
Biological Pathway
Exact Match
https://identifiers.org/reactome:R-H ...
Part Of
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
IRAK1 Recruits IKK Complex
IRAK4 Binds to the Activated TLR Receptor:TIRAP:MyD88 Complex
TIRAP Is Phosphorylated by BTK
Activated TLR2/4 Interacts with MAL (TIRAP)
IRAK4 Autophosphorylation in the Complex with Activated TLR:MyD88:TIRAP
MyD88 Forms a Complex with TIRAP:activated TLR2/4
Activated TLR2/4:TIRAP Interacts with BTK
MyD88 Oligomerization Within the Complex of Activated TLR:TIRAP:MyD88
Dissociation of Hp-IRAK1:TRAF6 From the Activated TLR:oligo-Myd88:TIRAP:p-IRAK4 Complex
MyD88-Dependent Toll-Like Receptor Signaling Pathway
TRAF6 Binds to Hp- IRAK1
TIRAP Binds PIP2-Rich Regions in the Plasma Membrane
IRAK1 or IRAK2 Binds to the Activated IRAK4 :Activated TLR:MyD88:TIRAP Complex
First Phosphorylation of IRAK1 by IRAK4 Bound to Activated TLR:MyD88:Mal
TRAF6 Binds to P-IRAK2
Dissociation of P-IRAK2:TRAF6 From the Activated TLR:oligo-Myd88:TIRAP:p-IRAK4 Complex
Toll Like Receptor TLR1:TLR2 Cascade
Second Phosphorylation of IRAK1 by IRAK4 Bound to Activated TLR:MyD88:TIRAP
Multiple IRAK1 Autophosphorylation Steps
Phosphorylation of IRAK2 Bound to the Activated IRAK4:MyD88 Oligomer:TIRAP:activated TLR Complex
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