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MyD88 Cascade Initiated on Plasma Membrane
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-975871).
Statements about
MyD88 Cascade Initiated on Plasma Membrane
Instance Of
Biological Pathway
MyD88-Dependent Toll-Like Receptor Signaling Pathway
Has Part(s)
16 items
IRAK1 Recruits IKK Complex
IRAK2 Mediated Activation of TAK1 Complex
TAK1-Dependent IKK and NF-Kappa-B Activation
MAP Kinase Activation
TRAF6 Binds MEKK1
Part Of
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 5 (TLR5) Cascade
Exact Match
https://identifiers.org/reactome:R-H ...
TRAF6 Binds to Hp- IRAK1 or P-IRAK2
IRAK4 Autophosphorylation Within the Complex Activated TLR:MyD88
IRAK4 Binds to MyD88 Bound to the Activated TLR5 or 10 Receptor
Phosphorylation of IRAK2 Bound to the Activated IRAK4:MyD88 Oligomerl:activated TLR5 or 10 Complex
IRAK1/Or IRAK2 Binds to the Activated IRAK4 :Oligo MyD88:activated TLR5 or 10 Complex
Dissociation of Hp-IRAK1:TRAF6 or IRAK2:TRAF6-Oligomer From the Activated TLR5 or 10:oligo-Myd88:p-IRAK4 Complex
First Phosphorylation of IRAK1 by IRAK4 Bound to MyD88:activated TLR
Multiple IRAK1 Autophosphorylation Within the Complex P-IRAK4:oligo MyD88:activated TLR
MyD88 Forms a Complex with the Activated TLR Receptor
Second Phosphorylation of IRAK1 by IRAK4 Bound to MyD88:activated TLR Complex
MyD88 Oligomerization Within the Complex of Activated TLR:MyD88
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