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Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Ontify

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1236382).

Statements about Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

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Instance Of

Biological Pathway

Part Of

Signaling by Ligand-Responsive EGFR Variants in Cancer

Has Part(s)

23 items

Binding of Ligand-Responsive EGFR Mutants to Chaperoning Proteins HSP90 and CDC37

Binding of EGF to Ligand-Responsive EGFR Mutants

EGF-Induced Dimerization of Ligand-Responsive EGFR Mutants

Trans-Autophosphorylation of Activated Ligand-Responsive EGFR Mutant Dimers

Spontaneous Dimerization of Ligand-Responsive EGFR Mutants

Binding of GRB2:SOS1 Complex to Phosphorylated Ligand-Responsive EGFR Mutants

SOS-Mediated Nucleotide Exchange of RAS (Mediated by GRB2:SOS1 in Complex with Ligand-Responsive P-6Y-EGFR Mutants)

Binding of SHC1 to P-6Y-EGFR Mutants

Phosphorylation of SHC1 by Ligand-Responsive P-6Y-EGFR Mutants

Phosphorylated SHC1 in Complex with Ligand-Responsive P-6Y-EGFR Mutants Recruits GRB2:SOS1 Complex

SOS-Mediated Nucleotide Exchange of RAS (Mediated by GRB2:SOS1 in Complex with Phosphorylated SHC1 and Ligand-Responsive P-6Y-EGFR Mutants)

Binding of GRB2:GAB1 Complex to Ligand-Responsive P-6Y-EGFR Mutants

Binding of PI3K to Complex of GRB2:GAB1 and Ligand-Responsive P-6Y-EGFR Mutants

Conversion of PIP2 to PIP3 by PI3K Bound to Ligand-Responsive P-6Y-EGFR Mutants

PLCG1 Binds to Ligand-Responsive P-6Y-EGFR Mutants

Phosphorylation of PLCG1 by Ligand-Responsive P-6Y-EGFR Mutants

Dissociation of Phosphorylated PLCG1 From Ligand-Responsive P-6Y-EGFR Mutants

Binding of CBL to Ligand-Responsive P-6Y-EGFR Mutants

Phosphorylation of CBL by Ligand-Responsive P-6Y-EGFR Mutants

Inefficient Ubiquitination of Ligand-Responsive P-6Y-EGFR Mutants by P-Y371-CBL

HSP90 Is Inactivated by Binding to Benzaquinoid Ansamycins

Non-Covalent Tyrosine Kinase Inhibitors Bind and Inactivate Sensitive Ligand-Responsive EGFR Cancer Mutants

Covalent Tyrosine Kinase Inhibitors Bind and Inactivate EGFR Kinase Domain Mutant Dimers Resistant to Non-Covalent Tyrosine Kinase Inhibitors

Exact Match

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