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Processing of DNA Double-Strand Break Ends - Ontify
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Processing of DNA Double-Strand Break Ends
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5693607).
Statements about
Processing of DNA Double-Strand Break Ends
Instance Of
Biological Pathway
Part Of
HDR Through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Has Part(s)
17 items
PIAS4 SUMOylates MDC1
RNF4 Ubiquitinates MDC1
SIRT6 Deacetylates RBBP8
MRN Complex Binds CDK2 and RBBP8
CDK2 Phosphorylates RBBP8
ATM Phosphorylates RBBP8
BRCA1 Binds Phosphorylated RBBP8
Initial Resection of Double-Strand Break Ends
EXO1 or DNA2 in Complex with BLM or WRN Binds Initially Resected DNA DSBs Along with BRIP1 Recruitment
Long-Range Resection of DNA DSBs by EXO1 or DNA2
Association of RPA Complexes with ssDNA at Resected DNA DSBs
Binding of ATR:ATRIP to RPA at Resected DNA DSBs
ATR Activation at DNA DSBs
ATR Phosphorylates RPA2
CHEK1 Is Recruited to Resected DNA DSBs
Activation of CHEK1 at Resected DNA DSBs
PPP4C:PPP4R2 Dephosphorylates RPA2
Exact Match
https://identifiers.org/reactome:R-H ...
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