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Hedgehog 'Off' State
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5610787).
Statements about
Hedgehog 'Off' State
Instance Of
Biological Pathway
Part Of
Signaling by Hedgehog
Has Part(s)
19 items
GLI3 Is Processed to GLI3R by the Proteasome
Degradation of GLI1 by the Proteasome
Degradation of GLI2 by the Proteasome
GLI Proteins Bind SUFU
KIF7 Is Recruited to the Ciliary Tip Through Interaction with Axonemal Microtubules
The Intraflagellar Transport B (IFT-B) Complex Is Required for the Transit of GLI:SUFU Complexes to the Ciliary Tip
The Intraflagellar Transport A (IFT-A) Complex Is Required for the Transit of GLI:SUFU Complexes to the Ciliary Base
GPR161 Promotes cAMP Production in a G Alpha(s)-Dependent Manner
Exact Match
https://identifiers.org/reactome:R-H ...
GLI3R Translocates to the Nucleus
CAMP Dissociates PKA, Promoting GLI Processing
Expression of GLI1 Is Repressed by GLI3R in the Absence of Hh Signaling
TULP3 Is Required for GPR161 Localization in the Cilium
GLI3R Binds the PTCH1 Promoter
Expression of PTCH1 Is Repressed by GLI3R in the Absence of Hh Signaling
Expression of GLI2 Is Repressed by GLI3R in the Absence of Hh Signaling
GLI3R Binds the GLI2 Promoter
GLI3R Binds the GLI1 Promoter
PTCH1 Inhibits Accumulation of SMO in the Primary Cilium in the Absence of Hh Signal
The IFT-A Complex Recruits TULP3
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