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Nonsense Mediated Decay (NMD) Enhanced by the Exon Junction Complex (EJC) - Ontify

Nonsense Mediated Decay (NMD) Enhanced by the Exon Junction Complex (EJC)

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-975957).

Statements about Nonsense Mediated Decay (NMD) Enhanced by the Exon Junction Complex (EJC)

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Instance Of

Biological Pathway

Part Of

Nonsense-Mediated Decay (NMD)

Has Part(s)

UPF1 Binds an mRNP with a Termination Codon Preceding an Exon Junction Complex

SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex)

P-4S-UPF1 Recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A

SMG6 Hydrolyzes mRNA with Premature Termination Codon

Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex

Exact Match

https://identifiers.org/reactome:R-H ...