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NIK-->noncanonical NF-kB Signaling - Ontify

NIK-->noncanonical NF-kB Signaling

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5676590).

Statements about NIK-->noncanonical NF-kB Signaling

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Instance Of

Biological Pathway

NIK/NF-kappaB Signaling

Part Of

TNFR2 Non-Canonical NF-kB Pathway

Has Part(s)

Activation of NIK

Active NIK Phosphorylates IKKA Dimer

P100:RELB Binds Active NIK:p-IKKA Dimer

Active NIK:p-S176,180-IKKA Dimer Phosphorylates P100:RELB

SCF-Beta-TRCP Binds P-7S-P100 in Active NIK:p-S176,180-IKKA Dimer:p-7S-P100:RELB

SCF-Beta-TRCP Ubiquitinates P-7S-P100:RELB in Active NIK:p-176,S180-IKKA Dimer:p-7S-P100:SCF-Beta-TRCP

26S Proteasome Processes P-7S-P100:RELB to Form P52:RELB

P52:RELB Translocates From Cytosol to Nucleus

NIK Autophosphorylates on T559

Exact Match

https://identifiers.org/reactome:R-H ...