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TNFR2 Non-Canonical NF-kB Pathway - Ontify

TNFR2 Non-Canonical NF-kB Pathway

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5668541).

Statements about TNFR2 Non-Canonical NF-kB Pathway

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Instance Of

Biological Pathway

Tumor Necrosis Factor-Mediated Signaling Pathway

Has Part(s)

12 items

TNFs Bind Their Physiological Receptors

NIK-->noncanonical NF-kB Signaling

TNF Receptor Superfamily (TNFSF) Members Mediating Non-Canonical NF-kB Pathway

TRAF3:NIK Binds TRAF2:cIAP1/2

CIAP1,2 Ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK

26Sproteasome Degrades K48polyUb-NIK

TNFA Binds TNFR2

2xTNFR2 Binds TNFA Trimer:TNFR2

CIAP1,2:TRAF2:TRAF3:NIK Complex Binds TNFR2 Trimer

TRAF2 Ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK

K63polyUb-cIAP1,2 Ubiquitinates TRAF3

Protesomal Degradation of K48polyUb-TRAF3

Part Of

Cytokine Signaling in Immune System

Exact Match

https://identifiers.org/reactome:R-H ...