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Activation of IRF3/IRF7 Mediated by TBK1/IKK Epsilon - Ontify
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Activation of IRF3/IRF7 Mediated by TBK1/IKK Epsilon
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-936964).
Statements about
Activation of IRF3/IRF7 Mediated by TBK1/IKK Epsilon
Instance Of
Biological Pathway
TRIF-Dependent Toll-Like Receptor Signaling Pathway
Part Of
TRIF(TICAM1)-Mediated TLR4 Signaling
Has Part(s)
Dimerization of Phosphorylated IRF3/IRF7
Dimerized Phospho-IRF3/IRF7 Is Transported to the Nucleus
TRAF3 Binds TICAM1:activated TLR4 Complex
Auto-Ubiquitination of TRAF3
TANK Binds K63-Poly-Ub-TRAF3:TICAM1:activated TLR4
TANK Is Ubiquitinated Within TANK:K63polyUb-TRAF3:TRIF:activated TLR4
Recruitment of TBK1/IKK Epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 Followed by Their Phosphorylation
IRF3/IRF7 Recruitment to P-TBK1/P-IKK Epsilon Bound to the Activated TLR4
Phosphorylation of IRF-3/IRF7 and Their Release From the Activated TLR Complex
Exact Match
https://identifiers.org/reactome:R-H ...
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