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IRAK2 Mediated Activation of TAK1 Complex upon TLR7/8 or 9 Stimulation - Ontify
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IRAK2 Mediated Activation of TAK1 Complex upon TLR7/8 or 9 Stimulation
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-975163).
Statements about
IRAK2 Mediated Activation of TAK1 Complex upon TLR7/8 or 9 Stimulation
Instance Of
Biological Pathway
Part Of
TRAF6 Mediated Induction of NFkB and MAP Kinases upon TLR7/8 or 9 Activation
Has Part(s)
Activated TRAF6 Synthesizes Unanchored Polyubiquitin Chains upon TLR Stimulation
IRAK2 Induces TRAF6 Oligomerization Initiated From Endosomal Compartments
Auto Ubiquitination of Oligo-TRAF6 Bound to P-IRAK2 at Endosome Membrane
Activated TRAF6:p-IRAK2 Interacts with TAK1 Complex upon TLR7/8 or 9 Stimulation
Auto Phosphorylation of TAK1 Bound to P-IRAK2:pUb Oligo-TRAF6: Free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 Activation
Exact Match
https://identifiers.org/reactome:R-H ...
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