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MyD88 Dependent Cascade Initiated on Endosome - Ontify

MyD88 Dependent Cascade Initiated on Endosome

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-975155).

Statements about MyD88 Dependent Cascade Initiated on Endosome

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Instance Of

Biological Pathway

Has Part(s)

12 items

TRAF6 Mediated Induction of NFkB and MAP Kinases upon TLR7/8 or 9 Activation

TRAF6 Mediated IRF7 Activation in TLR7/8 or 9 Signaling

MyD88 Interacts with the Activated TLR Receptor 7, 8 or 9

MyD88 Oligomerization Within the Complex of Activated TLR 7/8 or 9 : MyD88

IRAK4 Binds to the Activated TLR7/8 or 9 Receptor:MyD88 Complex

IRAK4 Autophosphorylation in the Complex with MyD88:activated TLR 7/8 or 9

IRAK1/Or IRAK2 Binds to the Activated IRAK4 :MyD88:activated TLR 7/8 or 9.

Phosphorylation of IRAK2 Bound to the Activated IRAK4:MyD88 Oligomer:activated TLR 7/8 or 9

First Phosphorylation of IRAK1 by IRAK4 Bound to MyD88:activated TLR 7/8 or 9

Second Phosphorylation of IRAK1 by IRAK4 Bound to MyD88: Activated TLR 7/8 or 9

Multiple IRAK1 Autophosphorylation Steps Within the Complex pIRAK4:MyD88:activated TLR7/8 or 9

TRAF6 Binds to Hp- IRAK1/Or P-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9

Part Of

Toll Like Receptor 7/8 (TLR7/8) Cascade

Toll Like Receptor 9 (TLR9) Cascade

Exact Match

https://identifiers.org/reactome:R-H ...