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Regulation of TP53 Degradation
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6804757).
Statements about
Regulation of TP53 Degradation
Instance Of
Biological Pathway
Has Part(s)
30 items
Ubiquitinated TP53 Translocates to the Cytosol
MDM2 Ubiquitinates Phosphorylated MDM4
Phosphorylation of MDM4 by CHEK2
Phosphorylation of MDM4 by ATM
MDM2 Binds TP53
MDM2 Forms Homo- or Heterodimers
MDM2 Ubiquitinates TP53
ATM Phosphorylates MDM2
P14ARF Forms a Ternary Complex with MDM2 and TP53
P14ARF Sequesters MDM2
TP53 Binds the MDM2 Gene
TP53 Stimulates MDM2 Transcription
AKT Phosphorylates MDM2
TORC2 Complex Phosphorylates SGK1
PDPK1 Phosphorylates SGK1
MDM2 Translocates to the Cytosol
SGK1 Phosphorylates MDM2
DAXX Binds Ub-MDM2 and USP7
MDM2 Translocates to the Nucleus
MDM2 Homodimers Auto-Ubiquitinate
USP7 Deubiquitinates MDM2
USP7 Deubiquitinates TP53 and Counteracts MDM2
USP2 Deubiquitinates MDM2,MDM4
TP53 Binds the CCNG1 Gene
(CDK1,CDK2):CCNA Phosphorylates MDM2 at T218
USP2 Binds the Heterodimer of MDM2 and MDM4
TP53 Stimulates CCNG1 Gene Expression
CCNG1 Recruits PP2A-PPP2R5C to MDM2
PP2A-PP2R5C Dephosphorylates MDM2
RNF34 or RFFL Ubiquitinates Phosphorylated TP53
Part Of
Regulation of TP53 Expression and Degradation
Exact Match
https://identifiers.org/reactome:R-H ...
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