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Activation of Matrix Metalloproteinases - Ontify

Activation of Matrix Metalloproteinases

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1592389).

Statements about Activation of Matrix Metalloproteinases

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Instance Of

Biological Pathway

Extracellular Matrix Disassembly

Part Of

Degradation of the Extracellular Matrix

Has Part(s)

27 items

Initial Activation of proMMP1

Autocatalytic Activation of MMP1

Full Activation of MMP1

MMP14 (MT1-MMP) Binds TIMP2

ProMMP9 Binds TIMP1

MMP14:TIMP2 Binds proMMP2

Initial Activation of proMMP2 by MMP1, 7

Autocatalytic Activation of proMMP2

Initial Activation of proMMP3

Initial Activation of proMMP2 by MMP14

Autocatalytic Activation of Bound proMMP2

Autocatalytic Activation of MMP3

Activation of proMMP7 by MMP3

Initial Activation of proMMP7 by Trypsin

Autocatalytic Activation of MMP7

Activation of proMMP8

Initial Activation of proMMP9 by MMPs

Activation of proMMP10

Activation of proMMP11 by FURIN

Activation of MMP9 Intermediate Form by MMPs

Activation of proMMP9 by Proteases

Initial Activation of proMMP13 by Plasmin and Trypsin

Initial Activation of proMMP13 by MMP3

Initial Activation of proMMP13 by MMP14 (MT1-MMP)

Autocatalytic Activation of proMMP13

Activation of MT-MMPs by FURIN

MT-MMPs Are Sorted to the Plasma Membrane

Exact Match

https://identifiers.org/reactome:R-H ...