Degradation of the Extracellular Matrix

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1474228).

46 items

Collagen Degradation

Activation of Matrix Metalloproteinases

HSPG2 (Perlecan) Degradation by MMP3, Plasmin, (MMP12)

MMP1,3,13 (2, 7-12, 19) Binding by Alpha-2 Macroglubulin

Basigin Binds Matrix Metalloproteinase-1

Has Part(s)

46 items

Collagen Degradation

Activation of Matrix Metalloproteinases

HSPG2 (Perlecan) Degradation by MMP3, Plasmin, (MMP12)

MMP1,3,13 (2, 7-12, 19) Binding by Alpha-2 Macroglubulin

Basigin Binds Matrix Metalloproteinase-1

Part Of

Extracellular Matrix Organization

Exact Match

https://identifiers.org/reactome:R-H ...

Fibronectin Degradation by MMP1, 3, 7, 12, 13, 19, CTSS

Elastin Degradation by MMP14

Fibronectin Degradation by MMP14, TMPRSS6

Fibronectin Degradation by MMP10

Fibronectin Degradation by ADAM8

HSPG2 (Perlecan) Is Cleaved by BMP1, TLL1, TLL2, Cathepsin L1

NID1 Degradation by MMP1, 9, 12, ELANE

Fibrillin-1 Degradation by ELANE

Fibrillin-1 Degradation by MMP3, CTSK, CTSL2

Laminin-322 Degradation by MMP14

HTRA1 Hydrolyzes ACAN (Aggrecan)

Elastin Degradation by Elastin-Degrading Extracellular Proteinases

HSPG2 (Perlecan) Degradation by MMP13, CTSS

Laminin-332 Degradation by Laminin-322 Degrading Extracellular Proteinases

Brevican Degradation by ADAMTS4, ADAMTS5

E-Cadherin Degradation by PS1:NCSTN (Gamma-Secretase)

E-Cadherin Degradation by MMP9, KLK7

MMP2, MMP7, MMP9 Bind CD44

DCN (Decorin) Degradation by MMP14

Aggrecan Degradation by MMP1,2,3,7,9,12,13

MMP7 Cleaves OPTC

Laminin-511 Degradation by MMP14

E-Cadherin Degradation by ADAM10, ADAM15

MMP2, MMP9 Cleave SCUBE3

E-Cadherin Degradation by Caspase-3 and Calpain-1

Fibronectin Degradation by CTSG

NID1 Degradation by MMP14, MMP15

Fibrillin-1 Degradation by MMP14

DCN (Decorin) Degradation by MMP2, MMP3, MMP7

Brevican Degradation by MMP1, 2, 3, 7,8,10,13,19

MMP2 Cleaves OPTC

CAPN:4xCa2+:CAPNS Cleave Cytoskeletal Proteins

MMP13 Cleaves OPTC

Aggrecan Degradation by ADAMTSs

OPN (Osteopontin) Degradation by MMP3, MMP7

Fibrillin 1, 2,(3) Degradation by MMP2, 9, 12 and 13

HSPG2 (Perlecan) Degradation by MMP14, MMP15

NID1 Degradation by MMP3, 7

E-Cadherin Degradation by MMP3, MMP7 and Plasmin.

SCUBE1, SCUBE3 Oligomerize

NID1 Degradation by MMP19

Degradation of the Extracellular Matrix

Degradation of the Extracellular Matrix

Statements about Degradation of the Extracellular Matrix

Instance Of

Has Part(s)

Part Of

Exact Match

Statements about Degradation of the Extracellular Matrix

Instance Of

Has Part(s)

Part Of

Exact Match