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Recruitment and ATM-Mediated Phosphorylation of Repair and Signaling Proteins at DNA Double Strand Breaks - Ontify
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Recruitment and ATM-Mediated Phosphorylation of Repair and Signaling Proteins at DNA Double Strand Breaks
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5693565).
Statements about
Recruitment and ATM-Mediated Phosphorylation of Repair and Signaling Proteins at DNA Double Strand Breaks
Instance Of
Biological Pathway
Has Part(s)
39 items
Phosphorylation and Activation of CHEK2 by ATM
P-T68-CHEK2 Dimerizes
CHEK2 Is Recruited to DNA DSBs
P-T68-CHEK2 Autophosphorylates
ATM Phosphorylates TP53 at S15
ATM Phosphorylates NBN
WICH Phosphorylates H2AFX on Y142
ATM Recognizes H2AFX-Nucleosomes
ATM Phosphorylates Histone H2AFX on S139 at DNA DSBs
APBB1 and MAPK8 Bind Diphosphorylated H2AFX
ATM Phosphorylates EYA1-4
EYA1-4 Dephosphorylates Tyrosine Y142 of H2AFX
MDC1 Associates with Gamma-H2AFX at Nuclear Foci
ATM Phosphorylates MDC1
WHSC1 Binds DNA DSBs
ATM Phosphorylates WHSC1
WHSC1 Dimethylates Histone H4 on Lysine K21 at DSBs
KDM4A,B Bind H4K20Me2
RNF8 Binds Phosphorylated MDC1 at DNA DSBs
HERC2 and PIAS4 Are Recruited to DNA DSBs
ATM Phosphorylates HERC2
PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
HERC2 Facilitates UBE2N:UBE2V2 Binding to RNF8
RNF168 Binds DNA DSBs
RNF8 and RNF168 Ubiquitinate H2AFX
RNF8 and RNF168 Ubiquitinate KDM4A,B
TP53BP1 Associates with H4K20Me2 at DNA DSBs
ATM Phosphorylates TP53BP1 at DNA DSBs
PPP5C Dephosphorylates TP53BP1
UIMC1 and FAM175A Bind DNA DSBs
BRCA1 Forms a Heterodimer with BARD1
Formation of BRCA1-A Complex at DNA DSBs
Phosphorylation of BRCA1-A Complex at Multiple Sites by ATM
CHEK2 Phosphorylates BRCA1
Activated ATM Phosphorylates ABL1
BRCA1:BARD1 Heterodimer Autoubiquitinates
BAP1 Binds BRCA1:BARD1 Heterodimer
BAP1 Disrupts the BRCA1:BARD1 Heterodimer
UBXN1 Binds BRCA1:BARD1 Heterodimer
Part Of
DNA Double Strand Break Response
Exact Match
https://identifiers.org/reactome:R-H ...
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