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POLB-Dependent Long Patch Base Excision Repair - Ontify
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POLB-Dependent Long Patch Base Excision Repair
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-110362).
Statements about
POLB-Dependent Long Patch Base Excision Repair
Instance Of
Biological Pathway
Part Of
Resolution of AP Sites via the Multiple-Nucleotide Patch Replacement Pathway
Has Part(s)
10 items
PARP1,PARP2 Dimers and FEN1 Bind POLB and Displace APEX1 From Damaged AP Site
POLB-Mediated DNA Strand Displacement Synthesis
PARP1,PARP2 Dimers Bound to FEN1 and POLB autoPARylate
PAR-PARP1,PAR-PARP2 Dissociate From FEN1 and POLB
PARG dePARylates PARP1,PARP2
FEN1 Bound to POLB Cleaves Displaced DNA Strand (Flap)
Exact Match
https://identifiers.org/reactome:R-H ...
LIG1 and POLB Dissociate From Repaired dsDNA
LIG1 Binds POLB at Long-Patch BER Site
ADPRHL2 Hydrolyses Poly(ADP-Ribose)
LIG1 Bound to POLB Ligates SSB
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