Ontify

⌘S

Oncogene Induced Senescence - Ontify

Oncogene Induced Senescence

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2559585).

Statements about Oncogene Induced Senescence

Powered by

Instance Of

Biological Pathway

Has Part(s)

19 items

MDM2 Ubiquitinates TP53

Association of INK4 Family Proteins with CDK4/6

MAPKs Phosphorylate ETS1 and ETS2

Phosphorylated ETS1 Binds P16INK4A Promoter

Phosphorylated ETS2 Binds P16INK4A Promoter

P-T38-ETS1/P-T72-ETS2 Stimulates Transcription of P16INK4A mRNA

ID1 Sequesters ETS2

ERF Binds ETS2 Promoter

ERF Inhibits ETS2 Expression

Activated ERKs Phosphorylate ERF

Phosphorylated ERF Translocates to the Cytosol

E2F1, E2F2, or E2F3 and SP1 Bind P14ARF Promoter

E2F1/E2F2/E2F3 and SP1 Stimulate Transcription of P14ARF mRNA

MiR-24 Binds P16INK4A and P14ARF mRNAs

Translation of P14ARF mRNA Is Inhibited by miR-24

Translation of P16INK4A mRNA Is Inhibited by miR-24

P14ARF Forms a Ternary Complex with MDM2 and TP53

P14ARF Sequesters MDM2

P14ARF Translocates to the Nucleus

Part Of

Cellular Senescence

Exact Match

https://identifiers.org/reactome:R-H ...