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Constitutive Signaling by NOTCH1 PEST Domain Mutants - Ontify

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2644606).

Statements about Constitutive Signaling by NOTCH1 PEST Domain Mutants

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Instance Of

Biological Pathway

Part Of

Signaling by NOTCH1 PEST Domain Mutants in Cancer

Has Part(s)

21 items

NOTCH1 PEST Domain Mutants Bind DLL1

NOTCH1 PEST Domain Mutants Bind DLL4

NOTCH1 PEST Domain Mutants Bind JAG1

NOTCH1 PEST Domain Mutants Bind JAG2

Ubiquitination of DLL/JAG Ligands upon Binding to NOTCH1 PEST Domain Mutants

ADAM10/17 Cleaves Ligand-Bound NOTCH1 PEST Domain Mutants to Produce NEXT1 PEST Domain Mutants

NEXT1 PEST Domain Mutants Are Cleaved to Produce NICD1 PEST Domain Mutants

NICD1 PEST Domain Mutants Translocate From Cytosol to Nucleus

NICD1 PEST Domain Mutants Displace Co-Repressor Complex From RBPJ (CSL)

NICD1 PEST Domain Mutants in Complex with RBPJ (CSL) Bind MAML

NOTCH1 PEST Domain Mutants Bind HES1 Promoter

NOTCH1 PEST Domain Mutants Stimulate HES1 Transcription

NOTCH1 PEST Domain Mutants Bind HES5 Promoter

NOTCH1 PEST Domain Mutants Stimulate HES5 Transcription

NOTCH1 PEST Domain Mutants Bind Promoters of HEY Genes

NOTCH1 PEST Domain Mutants Stimulate HEY Transcription

NOTCH1 PEST Domain Mutants Bind MYC Promoter

NOTCH1 PEST Domain Mutants Stimulate MYC Transcription

NOTCH1 PEST Domain Mutants Coactivator Complex Binds CDK8:CCNC

CDK8 Phosphorylates NICD1 PEST Domain Mutants

P-NICD1 PEST Domain Mutants Do Not Bind FBXW7

Exact Match

https://identifiers.org/reactome:R-H ...