Lovastatin Nonaketide Synthase Activity

Acyl-CoA:malonyl-CoA C-Acyltransferase (Decarboxylating, Oxoacyl- and Enoyl-Reducing, Thioester-Hydrolysing)

Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+).