Peptidyl-Diphthamide Biosynthetic Process From Peptidyl-Histidine

Peptidyl-Diphthamide Synthesis From Peptidyl-Histidine

The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria.