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Signaling by CSF3 (G-CSF) - Ontify

Signaling by CSF3 (G-CSF)

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9674555).

Statements about Signaling by CSF3 (G-CSF)

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Exact Match

https://identifiers.org/reactome:R-H ...

Instance Of

Biological Pathway

Cytokine-Mediated Signaling Pathway

Has Part(s)

13 items

CSF3 Dimer (GCSF Dimer) Binds CSF3R:JAK1:LYN

CSF3 Dimer:CSFR:LYN:JAK1 Binds CSFR:LYN:JAK1

CSF3 Dimer:2xCSF3R:LYN:JAK1 Induces Phosphorylation of JAK1

P-Y-JAK1 Phosphorylates CSF3R in CSF3 Dimer:2xCSF3R:LYN:p-Y-JAK1

CSF3 Dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 Binds and Activates JAK2, TYK2, SYK, and HCK

CSF3 Dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 Binds STAT1,3,5

P-Y-JAK1,2 Phosphorylates STAT1,3,5 in CSF3 Dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2

CSF3 Dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 Dissociates Yielding CSF3 Dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and P-Y-STAT1,3,5

P-Y-STAT1,3,5 Dimerize

P-Y-STAT1,3,5 Dimer Translocates From the Cytosol to the Nucleoplasm

CSF3 Dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 Binds and Phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)

P-Y546,Y584-PTPN11 (in CSF3 Dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) Dephosphorylates KRAS

Inactivation of CSF3 (G-CSF) Signaling

Part Of

Cytokine Signaling in Immune System