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Chaperone Mediated Autophagy - Ontify

Chaperone Mediated Autophagy

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9613829).

Statements about Chaperone Mediated Autophagy

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Exact Match

https://identifiers.org/reactome:R-H ...

Instance Of

Biological Pathway

Has Part(s)

19 items

HSPA8 Binds Substrate

HSPA8:Substrate Binds LAMP2a

HSPA8 Dissociates From LAMP2A-Bound Substrate

Substrate:LAMP2a Binds HSP90

Part Of

Chaperone-Mediated Autophagy

HSPA8 Binds LAMP2a Multimers

HSPA8:Substrate Dissociates From LAMP2a Multimer

Substrate:LAMP2a:HSP90 Polymerizes

HSP90 Dissociates From LAMP2a

P-GFAP:GFAP Dissociates From LAMP2a Multimer

EEF1A1:GTP Translocates From Lysosomal Membrane to Cytosol

HSPA8:LAMP2a Multimers Depolymerizes to Monomers

EEF1A1 Dissociates From P-GFAP

EEF1A1 Binds GTP

GFAP Binds LAMP2a Multimer

P-GFAP Binds EEF1A1

Unfolded Substrate in LAMP2a Multimeric Complex Binds HSPA8

PGFAP Binds GFAP in LAMP2a Multimer

HSPA8 Dissociates From LAMP2a

HSPA8 Transports Unfolded Substrate to Lysosomal Lumen for Degradation