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Aggrephagy - Ontify

Aggrephagy

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9646399).

Statements about Aggrephagy

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Exact Match

https://identifiers.org/reactome:R-H ...

Instance Of

Biological Pathway

Has Part(s)

15 items

ROS Positively Regulates Misfolding of Cilia Proteins

Misfolded Proteins Translocate From Cilium to Cytosol

E2 Enzyme UBE2N:UBE2V1 Binds Ubiquitin

Parkin Binds Ub:UBE2N:UBE2V1

Misfolded Proteins Bind PRKN:UBE2N:UBE2V1:Ub

Parkin Transfers Ub to Misfolded Proteins

Ub:misfolded Proteins Polymerize to PolyUb:misfolded Proteins

PolyUb:misfolded Proteins Dissociate From PRKN:UBE2N:UBE2V1

PolyUb-Misfolded Proteins Bind VCP:HDAC6:HSP90:HSF1

PolyUb-Misfolded Proteins:HDAC6 Dissociate From Complex

PolyUb-Misfolded Proteins:HDAC6 Bind Dynein Motor

Misfolded Proteins:HDAC6:Dynein Motor Binds Microtubule

Dynein Motors Transport Misfolded Proteins

PolyUb-Misfolded Proteins Bind Vimentin to Form Aggresome

Aggresome Dissociates From Dynein and Microtubule

Part Of

Selective Autophagy