Orly Alter

: Utah Science, Technology, and Research (USTAR) associate professor of bioengineering and human genetics at the Scientific Computing and Imaging Institute and the Huntsman Cancer Institute at the University of Utah

Principal Investigator

Title

: Multi-Tensor Decompositions for Personalized Cancer Diagnostics and Prognostics

Part Of

:

Physical Sciences in Oncology Network

:

:

Multi-Tensor Decomposition

Chief Scientific Officer

Part Of

:

Startup Company

Object Named As

:Prism AI Therapeutics, Inc.

:

:Prism AI Therapeutics, Inc.

Geneticist

Mathematician

Physicist

Family Name

Alter

Image

(January 2004)

Academic Degree

:

Postdoctoral Research

Award Received

:

DOE/Sloan Foundation Postdoctoral Fellowship in Computational Molecular Biology

Award Received

:

Individual Mentored Research Scientist Development Award

:

: January 2004

(January 1999)

:

:

: January 1999

(October 1989)

:

:

:

: October 1989

Influenced By

Gene H. Golub

Sex or Gender

Female

Country of Citizenship

Israel

United States

Name in Native Language

אורלי אלטר

Place of Birth

Tel Aviv

Field of Work

Genetics

Mathematics

Physics

Employer

University of Utah

University of Texas at Austin

Stanford University

Israeli Air Force

Date of Birth

April 1964

Languages Spoken, Written or Signed

Hebrew

Object of Statement Has Role

:

First Language

English

Student

Joel R. Meyerson

Field of Work

:

Biomedical Engineering

Field of Work

:

Government

Notable Work

27 items

Inhibition of the Measurement of the Wave Function of a Single Quantum System in Repeated Weak Quantum Nondemolition Measurements

Publisher

:

Physical Review Letters

Together With

:

Yoshihisa Yamamoto

DOI

:bug2: http://wikiba.se/ontology#ExternalId

Subject Has Role

:

Corresponding Author

Publication Date

: 5/22/1995

Singular Value Decomposition for Genome-Wide Expression Data Processing and Modeling

Publisher

:

Proceedings of the National Academy of Sciences of the United States of America

DOI

:bug2: http://wikiba.se/ontology#ExternalId

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 8/29/2000

Quantum Measurement of a Single System

:

:

:

:

:

Outstanding Doctoral Thesis Research in Atomic, Molecular, or Optical Physics (DAMOP) Award

Publication Date

: 5/25/2001

Generalized Singular Value Decomposition for Comparative Analysis of Genome-Scale Expression Data Sets of Two Different Organisms

Publisher

:

Proceedings of the National Academy of Sciences of the United States of America

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 3/11/2003

Integrative Analysis of Genome-Scale Data by Using Pseudoinverse Projection Predicts Novel Correlation Between DNA Replication and RNA Transcription

Publisher

:

Proceedings of the National Academy of Sciences of the United States of America

Together With

:

Gene H. Golub

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 11/15/2004

Reconstructing the Pathways of a Cellular System From Genome-Scale Signals by Using Matrix and Tensor Computations

Publisher

:

Proceedings of the National Academy of Sciences of the United States of America

Together With

:

Gene H. Golub

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 11/28/2005

Singular Value Decomposition of Genome-Scale mRNA Lengths Distribution Reveals Asymmetry in RNA Gel Electrophoresis Band Broadening

Publisher

:

Proceedings of the National Academy of Sciences of the United States of America

Together With

:

Gene H. Golub

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 8/8/2006

Discovery of Principles of Nature From Mathematical Modeling of DNA Microarray Data

Publisher

:

Proceedings of the National Academy of Sciences of the United States of America

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 10/31/2006

A Tensor Higher-Order Singular Value Decomposition for Integrative Analysis of DNA Microarray Data From Different Studies

Publisher

:

Proceedings of the National Academy of Sciences of the United States of America

Together With

:

Gene H. Golub

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 11/20/2007

Global Effects of DNA Replication and DNA Replication Origin Activity on Eukaryotic Gene Expression

Publisher

:

Molecular Systems Biology

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 10/13/2009

Tensor Decomposition Reveals Concurrent Evolutionary Convergences and Divergences and Correlations with Structural Motifs in Ribosomal RNA

Publisher

:

P L O S One

DOI

:bug2: http://wikiba.se/ontology#ExternalId

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 4/29/2011

A Higher-Order Generalized Singular Value Decomposition for Comparison of Global mRNA Expression From Multiple Organisms

Publisher

:

P L O S One

DOI

:bug2: http://wikiba.se/ontology#ExternalId

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 12/22/2011

GSVD Comparison of Patient-Matched Normal and Tumor aCGH Profiles Reveals Global Copy-Number Alterations Predicting Glioblastoma Multiforme Survival

Publisher

:

P L O S One

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 1/23/2012

SVD Identifies Transcript Length Distribution Functions From DNA Microarray Data and Reveals Evolutionary Forces Globally Affecting GBM Metabolism

Publisher

:

P L O S One

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 11/25/2013

Tensor GSVD of Patient- and Platform-Matched Tumor and Normal DNA Copy-Number Profiles Uncovers Chromosome Arm-Wide Patterns of Tumor-Exclusive Platform-Consistent Alterations Encoding for Cell Transformation and Predicting Ovarian Cancer Survival

Publisher

:

P L O S One

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 4/15/2015

Platform-Independent Genome-Wide Pattern of DNA Copy-Number Alterations Predicting Astrocytoma Survival and Response to Treatment Revealed by the GSVD Formulated as a Comparative Spectral Decomposition

Publisher

:

P L O S One

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 10/31/2016

Mathematically Universal and Biologically Consistent Astrocytoma Genotype Encodes for Transformation and Predicts Survival Phenotype

Publisher

:

APL Bioengineering

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 9/19/2018

GSVD- and Tensor GSVD-Uncovered Patterns of DNA Copy-Number Alterations Predict Adenocarcinomas Survival in General and in Response to Platinum

Publisher

:

APL Bioengineering

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 8/20/2019

Multi-Tensor Decompositions for Personalized Cancer Diagnostics, Prognostics, and Therapeutics

(January 2020)

:

:

:

Stanford Institute for Computational & Mathematical Engineering

Point in Time

: January 2020

Multi-Tensor Decompositions for Personalized Cancer Diagnostics, Prognostics, and Therapeutics

(January 2020)

:

:

: January 2020

Retrospective Clinical Trial Experimentally Validates Glioblastoma Genome-Wide Pattern of DNA Copy-Number Alterations Predictor of Survival

Publisher

:

APL Bioengineering

Subject Has Role

:

Principal Investigator

Subject Has Role

:

Corresponding Author

Publication Date

: 5/15/2020

Discovering Genome-Scale Predictors of Survival and Response to Treatment with Multi-Tensor Decompositions

(June 2020)

Subject Has Role

:

Lecturer

Participant

:

American Association for Cancer Research

Point in Time

: June 2020

Retrospective Clinical Trial Experimentally Validates Glioblastoma Genome-Wide Pattern of DNA Copy-Number Alterations Predictor of Survival

(September 2020)

Subject Has Role

:

Lecturer

Participant

:

Physical Sciences in Oncology Network

Point in Time

: September 2020

How High-Dimensional Multi-Tensor Machine Learning Is Being Used to Improve the Prognosis, Diagnosis, and Treatment of Gliomas

(November 2021)

Subject Has Role

:

Lecturer

Participant

:

Society for Neuro-Oncology (SNO)

Point in Time

: November 2021

Mathematical Discovery and Computational Validation of Two Orthogonal Mechanistically-Driven Whole-Genome Genotype–Survival Phenotype Relationships in Pediatric Neuroblastoma Nerve Cancer

Publisher

:

Association for Computing Machinery

Publisher

:

Institute of Electrical and Electronics Engineers

Subject Has Role

:

Principal Investigator

:

:

:bug: P5072

: 11/13/2023

AI/ML-Derived Whole-Genome Predictor Prospectively and Clinically Predicts Survival and Response to Treatment in Brain Cancer

Publisher

:

Association for Computing Machinery

Publisher

:

Institute of Electrical and Electronics Engineers

Subject Has Role

:

Principal Investigator

:

:

:bug: P5072

: 11/12/2023

Prism AI Presents: AI-Powered Biomarker Discovery for Personalized Medicine

(January 2024)

Subject Has Role

:

Lecturer

Participant

:

Precision Medicine World Conference (PMWC)

Point in Time

: January 2024

Nominated For

Outstanding Doctoral Thesis Research in Atomic, Molecular, or Optical Physics (DAMOP) Award

(1998)

For Work

:

Quantum Measurement of a Single System

Nominated By

:

American Physical Society

Point in Time

: 1998

Funder

United States Department of Energy

(1999 - 2003)

Title

: DOE/Sloan Foundation Postdoctoral Fellowship in Computational Molecular Biology: Analytical and Computational Tools for Genome-Wide Gene Expression Data Analysis

Together With

:

Alfred P. Sloan Foundation

Subject Has Role

:

Principal Investigator

Start Time

: 1999

End Time

: 2003

National Human Genome Research Institute

(2000 - 2005)

Title

: NIH/National Human Genome Research Institute (NHGRI) K01 Individual Mentored Research Scientist Development Award in Genomic Research and Analysis: Mathematical Tools for Genome-Wide Gene Expression Data Analysis

Part Of

:

United States National Institutes of Health

Subject Has Role

:

Principal Investigator

Start Time

: 2000

End Time

: 2005

National Human Genome Research Institute

(2007 - 2015)

Title

: NIH/National Human Genome Research Institute (NHGRI) R01 Project: Tensor Computations for Modeling Large-Scale Molecular Biological Data – from Discovery of Patterns to Discovery of Principles of Nature

Part Of

:

United States National Institutes of Health

Subject Has Role

:

Principal Investigator

Start Time

: 2007

End Time

: 2015

National Science Foundation Division of Mathematical Sciences

(2009 - 2015)

Title

: NSF/Division of Mathematical Sciences (DMS) Faculty Early Career Development (CAREER) Award: Integrative and Comparative Tensor Algebra Models of DNA Microarray Data from Different Studies of the Cell Cycle

Part Of

:

National Science Foundation

Subject Has Role

:

Principal Investigator

Start Time

: 2009

End Time

: 2015

National Cancer Institute

(2015 - 2023)

Title

: NIH/National Cancer Institute (NCI) Physical Sciences in Oncology U01 Project: Multi-Tensor Decompositions for Personalized Cancer Diagnostics and Prognostics

Part Of

:

United States National Institutes of Health

Subject Has Role

:

Principal Investigator

Start Time

: 2015

End Time

: 2023