A class of 2,6-diarylpyridazinones of general structural formula I have been identified that exhibit exhibit immunosuppressant activity with human T-lymphocytes, and are useful as an immunosuppressants or a pharmaceutically acceptable salt, hydrate or crystal form thereof, wherein: when M is S, R1 and R2 are selected from the following combinations: when R2 is 4-chloro, then R1 is 4-OCH3,2-CH3, 4-Cl, 4-CH3, 3-Cl, 3-CH3, 2-Cl, 4-H, 4-Br, 3-NO2; and when R2 is H, then R1 is 4-OCH3, and when M is -SO2-, then R2 is H and R1 is 4-OCH3. As an immunosuppressant, these compounds are useful in the treatment of autoimmune diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
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