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Interleukin-27 Signaling - Ontify
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Interleukin-27 Signaling
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9020956).
Statements about
Interleukin-27 Signaling
Has Part(s)
20 items
JAK1,JAK2,(TYK2) Bind IL6ST
CANX Binds EBI3
EBI3:CANX Binds IL27
CANX Dissociates From IL27:EBI3
Interleukin-27 Translocates From the ER Lumen to the Extracellular Region
SIL27RA Translocates From the Cytoplasm to the Extracellular Region
IL27RA Dimerizes
IL27RA Binds JAK1
Interleukin-27 Binds Interleukin-27 Receptor
Interleukin-27 Dissociates From Interleukin-27 Receptor
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) Are Phosphorylated
IL27RA and IL6ST Are Phosphorylated After IL27:IL27 Receptor Interaction and JAK's Phosphorylation
STAT1, STAT3 Bind P-Y611-IL27RA From Interleukin-27:Interleukin-27 Receptor Complex
STAT3 and STAT1 Are Phosphorylated by JAKs After IL27:IL27R Interaction
P-Y701-STAT1 and P-Y705-STAT3 Dissociate From IL27:IL27 Receptor
P-STAT1 Binds P-STAT3
P-Y701-STAT1:p-Y705-STAT3 Translocates to the Nucleus
IL27 Binds CRLF1
CRLF1:IL27 Translocates to the Extracellular Region
IL27 Translocates From the Cytosol to the Extracellular Space
Instance Of
Biological Pathway
Interleukin-27-Mediated Signaling Pathway
Exact Match
https://identifiers.org/reactome:R-H ...
Part Of
Interleukin-12 Family Signaling
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