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Interleukin-6 Signaling

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1059683).

Statements about Interleukin-6 Signaling

Has Part(s)

20 items

JAK1,JAK2,(TYK2) Bind IL6ST

IL6 Binds IL6R-2

IL6:IL6R-2 Binds IL6ST-2

IL6:IL6R-2 Binds IL6ST:JAK1, JAK2, (TYK2)

IL6:IL6R Binds IL6ST:JAK1,JAK2,(TYK2)

Assembly of Hexameric IL-6 Receptor

IL6ST Is Tyrosine Phosphorylated

Tyrosine Phosphorylated IL6ST Binds STAT1,STAT3

Tyrosine Phosphorylation of STAT1, STAT3 by IL6 Receptor

Serine Phosphorylation of STATs

Phosphorylated STATs Are Released

Phosphorylated STAT1, STAT3 Form Dimers

STAT1 and STAT3 Dimers Translocate to the Nucleus

PTPN11 Binds P-Y759-IL6ST

PTPN11 Is Phosphorylated

SOCS3 Binds IL6ST

PTPN11 Binds CBL

IL6R Binds IL6R Inhibitors

Instance Of

Biological Pathway

Interleukin-6-Mediated Signaling Pathway

Exact Match

https://identifiers.org/reactome:R-H ...

Part Of

Interleukin-6 Family Signaling

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