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Interleukin-2 Signaling - Ontify
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Interleukin-2 Signaling
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9020558).
Statements about
Interleukin-2 Signaling
Has Part(s)
19 items
IL2RG Binds JAK3
Interleukin-2: IL2 Receptor Alpha:beta Binds IL2 Receptor Gamma Subunit
Within the IL-2R Complex JAK3 Phosphorylates JAK1
JAK1 Phosphorylates Y338, Y392 and Y510 of IL2RB
Phosphorylation of IL2RB Y338 Enables SHC Recruitment
Phosphorylation of IL2RB Y338, Y392 or Y510 Enables STAT Recruitment
SHC1 Bound to IL2 Receptor Is Phosphorylated
Recruited STAT5 Is Phosphorylated
Phosphorylated STAT5 Is Released
P-STAT5 Dimerizes
STAT5 Dimers Translocate to the Nucleus
SYK Binds IL2RB
SYK Is a Substrate for JAK1
JAK3 Binds JAK3 Inhibitors
Instance Of
Biological Pathway
Exact Match
https://identifiers.org/reactome:R-H ...
Part Of
Interleukin-2 Family Signaling
Interleukin-2 Receptor Alpha Binds Interleukin-2
Interleukin-2 Receptor Alpha:IL2 Binds Interleukin-2 Receptor Beta
PTK2B Is Phosphorylated
IL2RB Binds JAK1
PTK2B Binds JAK3
Interleukin-2-Mediated Signaling Pathway
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