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GRB2-1:SOS1 [Cytosol] - Ontify
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GRB2-1:SOS1 [Cytosol]
Instance of macromolecular complex in Homo sapiens with Reactome ID (R-HSA-109797).
Statements about
GRB2-1:SOS1 [Cytosol]
Instance Of
Protein Complex
Has Part(s)
Growth Factor Receptor Bound Protein 2
SOS Ras/Rac Guanine Nucleotide Exchange Factor 1
Exact Match
https://identifiers.org/reactome:R-H ...
Part Of
99 items
FGFR4 Mutants:p-FRS2:GRB2:SOS1 [Plasma Membrane]
GRB2:SOS1 Binds to Phosphorylated SHC1 in Complex with EGFR
NTF3:p-5Y-NTRK3 Homodimer:p-Y-SHC1:GRB2:SOS1 [Plasma Membrane]
NTRK3 Binds GRB2:SOS1 Through SHC1
P-6Y-ERBB2 TMD/JMD Mutants (RAS):EGF:p-6Y-EGFR:GRB2:SOS1 [Plasma Membrane]
Activated FGFR2:p-SHC1 Binds GRB2:SOS1
GRB2:SOS1 Complex Binds to Mutant PDGFR Receptor
Activated FGFR3:p-SHC1 Binds GRB2:SOS1
KIT Mutants Bind GRB2-SOS
2x P-5Y-RET:GDNF:GFRA Complexes Bind GRB2-1:SOS1
Phosphorylated Heterodimers of ERBB2 KD Mutants and EGFR Bind GRB2:SOS1
Activated FGFR1:p-FRS2:GRB2:SOS1 [Plasma Membrane]
Activated FGFR2 Mutants:p-FRS2 Binds GRB2-SOS1
Phosphorylated SHC Recruits GRB2:SOS1
GRB2:SOS1 Binds to Phosphorylated Heterodimers of ERBB2 ECD Mutants and EGFR
GRB2:SOS1 Complex Binds to EGF:EGFR Complex
Binding of GRB2:SOS1 Complex to Phosphorylated Ligand-Responsive EGFR Mutants
Activated FGFR4 Mutants:p-FRS2 Binds GRB2-SOS1
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [Plasma Membrane]
P-11Y PDGFR Mutatnt Receptors:GRB2:SOS1 [Plasma Membrane]
Activated FGFR3:pFRS Binds GRB2:SOS1
FGFR2 Mutants:p-FRS2:GRB2:SOS1 [Plasma Membrane]
GRB2-1:SOS1:p-Y427-SHC1 [Cytosol]
HGF:p-4Y-MET Dimer:p-Y317-SHC1-2:GRB2:SOS1 [Plasma Membrane]
NTRK2-Phosphorylated FRS2 Binds GRB2
Activated FGFR1:p-SHC1:GRB2:SOS1 [Plasma Membrane]
Phosphorylated Heterodimers of ERBB2 TMD/JMD Mutants and EGFR Bind GRB2:SOS1
P-KIT Mutants:GRB2:SOS [Plasma Membrane]
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 Heterodimers [Plasma Membrane]
Phosphorylated Heterodimers of ERBB2 TMD/JMD Mutants Recruit GRB2:SOS1 Through SHC1
Activated FGFR3:p-FRS:GRB2:SOS1 [Plasma Membrane]
Phosphorylated SHC1 in Complex with Ligand-Responsive P-6Y-EGFR Mutants Recruits GRB2:SOS1 Complex
2x P-5Y-RET:GDNF:GFRA Complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [Plasma Membrane]
GRB2-1:SOS1 Binds P-3Y-SHC1
Activated FGFR4:p-FRS Binds GRB2:SOS1
Activated FGFR4:p-SHC1 Binds GRB2:SOS1
GRB2-1:SOS1:p-3Y-SHC1 [Cytosol]
GRB2-1 Binds SOS1
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [Plasma Membrane]
Activated FGFR2:p-FRS:GRB2:SOS1 [Plasma Membrane]
EGF-Like Ligands:p-6Y-EGFR:GRB2:SOS1 [Plasma Membrane]
P-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [Plasma Membrane]
P-6Y-ERBB2 TMD/JMD Mutants:Ligand-Activated P-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [Plasma Membrane]
2x P-5Y-RET:GDNF:GFRA Complexes:p-Y349,Y350,Y427-SHC1 Binds GRB2-1:SOS1
GRB2:SOS1 Complex Binds to PDGFRA Extracellular Domain Dimers
Activated FGFR3:pY-SHC1:GRB2:SOS1 [Plasma Membrane]
Phosphorylated SHC1 in Complex with P-5Y-EGFRvIII Recruits GRB2:SOS1 Complex
Interleukin Receptor Complexes with Activated SHC1:GRB2:SOS1 [Plasma Membrane]
Ligand-Responsive P-6Y-EGFR Mutants:GRB2:SOS1 [Plasma Membrane]
Activated FGFR2:pY-SHC1:GRB2:SOS1 [Plasma Membrane]
Activated FGFR1 Mutants:p-FRS2 Binds GRB2-SOS1
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [Cytosol]
GRB2-1:SOS1 Binds P-Y427-SHC1
Phosphorylated Heterodimers of ERBB2 KD Mutants Recruit GRB2:SOS1 Through SHC1
Ligand Responsive P-6Y-EGFR Mutants:p-Y349,350-SHC1:GRB2:SOS1 [Plasma Membrane]
SHC1 Bound to Activated NTRK2 Recruits GRB2:SOS1
Phosphorylated Heterodimers of ERBB2 KD Mutants:p-Y349,Y350-SHC1:GRB2:SOS1 [Plasma Membrane]
P-6Y-ERBB2 ECD Mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1:GRB2:SOS1 [Plasma Membrane]
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [Plasma Membrane]
Recruitment of GRB2:SOS1 to Phosphorylated SHC1 in Complex with Phosphorylated ERBB4 Homodimers
Activated FGFR4:p-FRS2:GRB2:SOS1 [Plasma Membrane]
SHC1-2 Bound to MET Recruits GRB2:SOS1
Recruitment of GRB2:SOS1 to P-SHC1 in Complex with Phosphorylated ERBB2 Homodimer
GRB2-1:SOS1:p-Y-SHC [Cytosol]
GRB2-1:SOS1 Binds P-Y-SHC
GRB2:SOS1 Complex Binds Phosphorylated EGFR:ERBB2 Heterodimer
GRB2:SOS1:p-KIT Complex [Plasma Membrane]
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [Plasma Membrane]
Recruitment of GRB2:SOS1 to P-SHC1 in Complex with Phosphorylated ERBB2 Heterodimers
GRB2:SOS Interacts with P-KIT
Activated FGFR2:pFRS Binds GRB2:SOS1
FGFR3 Point, Translocation and Fusion Mutants:p-FRS2:GRB2:SOS1 [Plasma Membrane]
P-5Y-EGFRvIII:GRB2:SOS1 [Plasma Membrane]
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [Plasma Membrane]
PDGF:Phospho-PDGF Receptor Dimer:Grb2:Sos1 [Plasma Membrane]
HGF:p-4Y-MET Dimer:GRB2-1:SOS1 [Plasma Membrane]
Phosphorylated Heterodimers of ERBB2 ECD Mutants and EGFR Recruit GRB2:SOS1 Through SHC1
Activated MET Recruits GRB2-1:SOS1
EGF-Like Ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [Plasma Membrane]
GRB2:SOS1 Binds to HBEGF:p-Y-EGFR
Activated FGFR4:pY-SHC1:GRB2:SOS1 [Plasma Membrane]
Activated FGFR1:p-FRS Binds GRB2:SOS1
GRB2-1:SOS1 Binds P-IRS1,p-IRS2
Interaction of GRB2:SOS Complex with P-SHC1
Activated FGFR3 Point, Translocation and Fusion Mutants:p-FRS2 Binds GRB2-SOS1
P-SHC1:GRB2:SOS [Cytosol]
P-11Y PDGFRA Extracellular Domain Dimers:GRB2:SOS1 [Endoplasmic Reticulum Membrane]
2x P-5Y-RET:GDNF:GFRA Complexes:GRB2-1:SOS1 [Plasma Membrane]
GRB2:SOS1:HB-EGF:p-6Y-EGFR [Plasma Membrane]
FGFR1 Mutants:p-FRS2:GRB2:SOS1 [Plasma Membrane]
GRB2:SOS1 Complex Binds to the Active Receptor
GRB2:SOS1 Complex Binds Phosphorylated ERBB4:ERBB2 Heterodimers
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Binding of GRB2:SOS1 Complex to Phosphorylated EGFRvIII
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 Binds GRB2:SOS1
Activated FGFR1:p-SHC1 Binds GRB2:SOS1
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [Plasma Membrane]
P-6Y-ERBB2 ECD Mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [Plasma Membrane]
P-6Y-ERBB2 KD Mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [Plasma Membrane]
P-ERBB2 Homodimer:p-Y349,Y350-SHC1:GRB2:SOS1 [Plasma Membrane]
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