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BCDX2 Complex [Nucleoplasm] - Ontify

BCDX2 Complex [Nucleoplasm]

Instance of macromolecular complex in Homo sapiens with Reactome ID (R-HSA-5685316).

Statements about BCDX2 Complex [Nucleoplasm]

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Instance Of

Protein Complex

Has Part(s)

RAD51 Paralog C

X-Ray Repair Cross Complementing 2

RAD51 Paralog D

RAD51 Paralog B

Exact Match

https://identifiers.org/reactome:R-H ...

Part Of

14 items

Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C Complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [Nucleoplasm]

Resolution of D-Loops Cleaved by MUS81:EME1 or MUS81:EME2

Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C Complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [Nucleoplasm]

3' Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 Complex [Nucleoplasm]

BLM Mediates Dissolution of Double Holliday Junction

Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C Complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [Nucleoplasm]

BCDX2 Complex Stabilizes RAD51 Filament

Resolution of Holliday Junctions Cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)

BCDX2 Complex Formation

D-Loop Dissociation and Strand Annealing

D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C Complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [Nucleoplasm]

Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C Complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [Nucleoplasm]

3' Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 Mutants (PALB2 Binding):SEM1:BCDX2 Complex [Nucleoplasm]

Defective 3' Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 Complex [Nucleoplasm]

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