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Clathrin-Mediated Endocytosis - Ontify

Clathrin-Mediated Endocytosis

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8856828).

Statements about Clathrin-Mediated Endocytosis

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Instance Of

Biological Pathway

Part Of

Membrane Trafficking

Has Part(s)

21 items

Cargo Recognition for Clathrin-Mediated Endocytosis

Initial Binding of AP-2 and Clathrin to PI(4,5)P2

FCHo Proteins Bind Nascent Clathrin-Coated Pit

Recruitment of AP-2 Complex and Clathrin

PIP5K1C Phosphorylates PI(4)P to PI(4,5)P2

AAK1 Phosphorylates AP-2 Mu Subunit at T156

CLASP Proteins and Cargo Are Recruited to the Nascent Clathrin-Coated Pit

Clathrin Recruits PIK3C2A

Clathrin-Associated PIK3C2A Phosphorylates PI(4)P to PI(3,4)P2

F- and N- BAR Domain Proteins Bind the Clathrin-Coated Pit

SNX9 Recruits Components of the Actin Polymerizing Machinery

BAR Domain Proteins Recruit Dynamin

Endophilins Recruit Synaptojanins to the Clathrin-Coated Pit

SYNJ Hydrolyze PI(4,5)P2 to PI(4)P

Dynamin-Mediated GTP Hydrolysis Promotes Vesicle Scission

Clathrin Recruits Auxilins to the Clathrin-Coated Vesicle

Auxilin Recruits HSPA8:ATP to the Clathrin-Coated Vesicle

HSPA8-Mediated ATP Hydrolysis Promotes Vesicle Uncoating

RAB5 and GAPVD1 Bind AP-2

Dissociation of AAK1 and Dephosphorylation of AP-2 Mu2

Dissociation of Clathrin-Associated Proteins

Exact Match

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