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LDL Clearance - Ontify
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LDL Clearance
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8964038).
Statements about
LDL Clearance
Instance Of
Biological Pathway
Low-Density Lipoprotein Particle Clearance
Part Of
Plasma Lipoprotein Clearance
Has Part(s)
20 items
CES3 Hydrolyses CHEST to CHOL and LCFA(-)
LSR Trimer Binds LDL
LDL + LDLR => LDL:LDLR Complex
LDL:LDLR Complex [Plasma Membrane] => LDL:LDLR Complex [Clathrin-Coated Vesicle] (LDLRAP1-Independent)
LDLR:LDL Complex [Coated Vesicle Membrane] => LDLR:LDL Complex [Endosome Membrane]
LDLR:LDL Complex => LDLR + LDL
LDL Translocates From Endosome Lumen to Lysosome Lumen
LIPA Hydrolyses Sterol Esters to Sterols and Fatty Acids
NPC2 Binds CHOL
NPC2 Transfers CHOL to NPC1
CHOL Translocates From Lysosome Membrane to ER Membrane
SOAT1,2 Transfer Acyl Group to CHOL Forming CHEST
CHEST Translocates From ER Membrane to Lipid Particle
NCEH1 Hydrolyzes Cholesterol Esters
LDLR [Endosome Membrane] => LDLR [Plasma Membrane]
PCSK9 Binds LDLR
PCSK9:LDLR Bind to Clathrin
PCSK9:LDLR:Clathrin-Coated Vesicle Transport From Plasma Membrane to Endolysosome
Degradation of PCSK9:LDLR:Clathrin-Coated Vesicle
PCSK9 Binds PCSK9 Inhibitors
Exact Match
https://identifiers.org/reactome:R-H ...
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