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RHO GTPases Activate Formins - Ontify

RHO GTPases Activate Formins

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5663220).

Statements about RHO GTPases Activate Formins

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Instance Of

Biological Pathway

Part Of

RHO GTPase Effectors

Has Part(s)

27 items

PpDVL Binds DAAM1

DAAM1 Recruits GTP-Bound RHOA

FMNL1 Binds RAC1:GTP

Association of Profilin with Monomeric Actin

RAC1:GTP:FMNL1 Binds Profilin:G-Actin

SRGAP2 Binds RAC1:GTP:FMNL1:profilin:G-Actin

SRGAP2 Stimulates RAC1 GTP-Ase Activity and Ends FMNL1-Mediated Elongation of Actin Filaments

FMNL1 Binds CDC42:GTP

FMNL2 Binds CDC42:GTP

CDC42:GTP:FMNL2 Binds Profilin:G-Actin

FMNL2 Binds RHOC:GTP

FMNL3 Binds RHOC:GTP

Activated FMNL3 Binds G-Actin

Profilin:G-Actin Binds MKL1

DIAPH1 Binds RHOA:GTP

RHOA:GTP:DIAPH1 Binds EVL and Sequesters Profilin:G-Actin From MKL1

MKL1 Translocates From Cytosol to the Nucleus

SCAI Binds SRF:MKL1

SRF:MKL1 Binds ITGB1 Gene

SRF:MKL1 Stimulate ITGB1 Expression While SCAI Inhibits It

RHOB:GTP Recruits DIAPH1 or DIAPH3 to Endosomes

RHOD:GTP Recruits DAIPH2-3 to Endosomes

RHOD:GTP:DIAPH2-3 Recruits SRC-1 to Endosomes

CDC42:GTP Recruits DIAPH2-2 to Kinetochores

AURKB Phosphorylates DIAPH2-2 at Kinetochores

Kinetochore Capture of Astral Microtubules Is Positively Regulated by CDC42:GTP:p-S196-DIAPH2-2

Exact Match

https://identifiers.org/reactome:R-H ...