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MAPK6/MAPK4 Signaling - Ontify

MAPK6/MAPK4 Signaling

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5687128).

Statements about MAPK6/MAPK4 Signaling

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Instance Of

Biological Pathway

Part Of

MAPK Family Signaling Cascades

Has Part(s)

40 items

Activation of PAKs by RAC1 and CDC42

Autophosphorylation of PAK1,2,3

PAK1,2,3 Phosphorylates MAPK6,4

MAPK4,6 Translocate to Nucleus

MAPK4,6 Translocate to the Cytoplasm

MAPK6 Is Ubiquitinated at the N-Terminal

MAPK6 Is Degraded by the 26S Proteasome

CDK1 Phosphorylates MAPK6

CDC14A,B Bind MAPK6

CDC14A,B Dephosphorylate P-3S,T MAPK6

P-S MAPK6 Phosphorylates NCOA3

MAPK6 Binds CCND3

P-S857 NCOA3 Binds ETV4

P-S857 NCOA3:ETV4 Bind MMP2 and MMP10 Promoter

P-S MAPK6,4 Binds MAPKAPK5

P-S MAPK6,4 Phosphorylate MAPKAPK5

P-S MAPK6,4:p-T182 MAPKAPK5 Translocate to the Cytosol

P-S182 MAPKAPK5 Phosphorylates FOXO1

P-S215 FOXO1 Binds RAG Gene

P-S215 FOXO1 Positively Regulates RAG Gene Expression

PKA Phosphorylates MAPKAPK5

P-S115 MAPKAPK5 Translocates to the Cytosol

P-S MAPKAPK5 Phosphorylates HSPB1

P-T182 MAPKAPK5 Binds DNAJB1

P-T182-MAPKAPK5 Phoshphorylates DNAJB1

P-T182 MAPKAPK5 Phosphorylates FOXO3

P-S215 FOXO3 Translocates to the Nucleus

P-S215 FOXO3 Binds MIR34B and C Gene

FOXO3 Regulates MIR34B,C Expression

MYC mRNA Translation Is Negatively Regulated by miR-34B and C

MYC Binds MAPKAPK5 Gene

MYC Positively Regulates MAPKAPK5 Gene Expression

IGF2BP1 Binds MAPK4 mRNA

IGF2BP1 Represses Translation of MAPK4 mRNA

SEPT7 Binds P-S189 MAPK6 and P-T182 MAPKAPK5

SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 Phosphorylates CDC42EPs

P-S189 MAPK6:p-T182 MAPKAPK5 Bind KALRN

MAPKAPK5 Phosphorylates KALRN

JUN Binds MAPK6 Gene

JUN Positively Regulates MAPK6 Gene Expression

Exact Match

https://identifiers.org/reactome:R-H ...