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Hedgehog 'On' State - Ontify
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Hedgehog 'On' State
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5632684).
Statements about
Hedgehog 'On' State
Instance Of
Biological Pathway
Part Of
Signaling by Hedgehog
Has Part(s)
23 items
Ligand-Receptor Interactions
SMURF1/2 Bind PTCH1
SMURF1/2 Ubiquitinates PTCH1
SMURF1/2 Dissociates From Ub-PTCH1
PTCH Is Internalized
NUMB:ITCH Ubiquitinates GLI1
Ub-GLI Is Degraded by the Proteasome
Exact Match
https://identifiers.org/reactome:R-H ...
NUMB Binds ITCH
GLI Proteins Bind SUFU
SPOP:CUL3:RBX1 Ubiquitinates GLI2,3
Activation of SMO
GPR161 Is Internalized
GLI Proteins Bind Promoters of Hh Responsive Genes to Promote Transcription
NUMB:ITCH Binds GLI1
ULK3:SUFU Dissociates
GLI Proteins Are Phosphorylated
GLI:SUFU Translocates to the Ciliary Tip in Response to Hh Signaling
Phosphorylated GLI Proteins Bind SPOP:CUL3:RBX1
GLI:SUFU Dissociates
GLI2,3 Are Degraded by the Proteasome
GLI Translocates to the Nucleus
ULK3 Phosphorylates GLI
GLI Proteins Bind CDC73
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