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Signaling by Hippo - Ontify

Signaling by Hippo

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2028269).

Statements about Signaling by Hippo

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Instance Of

Biological Pathway

Part Of

Signal Transduction

Has Part(s)

30 items

Exact Match

https://identifiers.org/reactome:R-H ...

Cleavage of P-STK4 (P-MST1) by Caspase 3

Phosphorylation of MOB1A and B by P-STK4 (P-MST1)

Phosphorylation of WWTR1 (TAZ) by LATS2

Phosphorylation of MOB1A and B by P-STK3 (P-MST2)

Phosphorylated MOB1A Proteins Associate with LATS Proteins

Phosphorylation of MOB1A and B by P-STK4(MST1)/N

YAP1 Binds ZO-2 (TJP2)

Translocation of WWTR1 (TAZ) to the Nucleus

Phosphorylation of LATS1 and 2 by P-STK4 (P-MST1)

Phosphorylation of YAP by LATS1

Phosphorylation of WWTR1 (TAZ) by LATS1

Translocation of YAP1:ZO-2 (TJP2) to the Nucleus

Phosphorylation of LATS1 and 2 by P-STK3 (MST2)/N

YWHAE (14-3-3 Epsilon) Dimer Binds Phosphorylated WWTR1 (TAZ)

Phosphorylation of MOB1A and B by P-STK3(MST2)/N

NPHP4 Protein Binds LATS Proteins

Phosphorylation of LATS1 and 2 by P-STK3 (P-MST2)

WWTR1 (TAZ) Binds ZO-2 (TJP2)

Phosphorylation of YAP by LATS2

AMOT Proteins Bind YAP1

Phosphorylation of STK4 (MST1) and SAV1 by STK4

Hippo Signaling

YWHAB (14-3-3 Beta/Alpha) Dimer Binds Phosphorylated YAP1

AMOT Proteins Bind WWTR1 (TAZ)

KIBRA (WWC1) Binds LATS Proteins

Cleavage of P-STK3 (P-MST2) by Caspase 3

Translocation of YAP1 to the Nucleus

Phosphorylation of LATS1 and 2 by P-STK4(MST1)/N

Phosphorylation of STK3 (MST2) and SAV1 by STK3

DVL2 Binds Phosphorylated WWTR1 (TAZ)

WWTR1 (TAZ) Binds ZO-1 (TJP1)