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Ca2+ Pathway
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-4086398).
Statements about
Ca2+ Pathway
Instance Of
Biological Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Part Of
Beta-Catenin Independent WNT Signaling
Has Part(s)
27 items
IP3 Binds to the IP3 Receptor, Opening the Endoplasmic Reticulum Ca2+ Channel
Activation of Calcineurin
Gbeta:gamma Activation of PLC Beta
PLC Beta-Mediated PIP2 Hydrolysis
WNT5A and WNT11 Bind FZD Receptors to Initiate Ca2+ Signaling
FZD Recruits Trimeric G-Proteins
WNT:FZD Complex Promotes G-Protein Nucleotide Exchange
G-Protein Subunits Dissociate From WNT:FZD Complex
Translocation and Activation of PKC Alpha in Response to WNT Signaling
Calcineurin Binds and Dephosphorylates NFAT1 in Response to WNT/Ca2+ Signaling
Translocation of NFATC1:CaN:CaM to Nucleus
Decreasing cGMP Concentration Promotes Intracellular Ca2+ Release in Response to WNT
G Alpha T2 Binds and Activates PDE6
Active Calmodulin Binds CAMK2
PRKG Is Activated by Binding to High Levels of cGMP in the Absence of WNT Signaling
Autophosphorylation and Activation of CAMK2
Dissociation of CaM and CAMK2 Autophosphorylation
CAMK2 Binds MAP3K7
Activation of MAP3K7 in Response to WNT
Activation of NLK
NLK Translocates to Nucleus
NLK Phosphorylates TCF/LEF
MiR-92b Binds 3'UTR of NLK mRNA
NLK mRNA Translation Controlled by miR-92b
TCF/LEF:CTNNB1 Bind Canonical WNT Target Promoters
Transcription of Canonical WNT Targets Is Negatively Regulated by NLK-Dependent Phosphorylation of TCF/LEF
PDE6 Hydrolyses cGMP to GMP
Exact Match
https://identifiers.org/reactome:R-H ...
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