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Activated NOTCH1 Transmits Signal to the Nucleus
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2122948).
Statements about
Activated NOTCH1 Transmits Signal to the Nucleus
Instance Of
Biological Pathway
Notch Signaling Pathway
Part Of
Signaling by NOTCH1
Has Part(s)
21 items
NOTCH1 Binds DLL1
NOTCH1 Binds DLL4
NOTCH1 Binds JAG1
NOTCH1 Binds JAG2
Ubiquitination of DLL/JAG Ligands upon Binding to NOTCH1
Complex of NOTCH1 with Its Ligand Is Cleaved to Produce NEXT1
NEXT1 Is Cleaved to Produce NICD1
NICD1 Traffics to Nucleus
DTX Binds NOTCH1
Contactin-1 (CNTN1) Binds NOTCH1
Cleavage of CNTN1:NOTCH1 Complex Releases NICD1
NOTCH1 Binds DNER
Cleavage of DNER:NOTCH1 Complex Releases NICD1
DTX Recruits Beta-Arrestin (ARRB) to NOTCH
ARRB Mediates NOTCH1 Ubiquitination
ITCH Binds DTX
ITCH Ubiquitinates DTX
NOTCH1 Binds DLL/JAG Ligand in Cis
NOTCH1 Binds DLK1
NOTCH1 Associates with Negative Regulators NUMB and ITCH
Ubiquitination of NOTCH1 by ITCH in the Absence of Ligand
Exact Match
https://identifiers.org/reactome:R-H ...
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