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Signaling by BMP
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-201451).
Statements about
Signaling by BMP
Instance Of
Biological Pathway
BMP Signaling Pathway
Part Of
Signaling by TGFB Family Members
Has Part(s)
17 items
The Ligand Trap Binds the Ligand BMP2, Blocking BMP Signalling
Formation of a Heteromeric BMP Receptor Complex
BMP2 Binds to the Receptor Complex
Type II Receptor Phosphorylates Type I Receptor
An Anchoring Protein, Endofin, Recruits R-Smad1/5/8
Ubiquitin-Dependent Degradation Controls Basal Levels of R-Smad1/5/8
I-Smad Binds to Type I Receptor, Preventing Smad1/5/8 From Being Activated
Activated Type I Receptor Phosphorylates R-Smad1/5/8 Directly
Phospho-R-Smad1/5/8 Dissociates From the Receptor Complex
I-Smad Competes with Co-Smad for R-Smad1/5/8
Phospho-R-Smad1/5/8 Forms a Complex with Co-Smad
The Phospho-R-Smad1/5/8:Co-Smad Transfers to the Nucleus
Ubiquitin-Dependent Degradation of the Smad Complex Terminates BMP2 Signalling
SKI Complexes with the Smad Complex, Suppressing BMP2 Signalling
I-Smad Competes with R-Smad1/5/8 for Type I Receptor
AMHR2 Binds AMH
ACVRL1 Binds BMP9,BMP10
Exact Match
https://identifiers.org/reactome:R-H ...
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