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Downregulation of TGF-Beta Receptor Signaling - Ontify
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Downregulation of TGF-Beta Receptor Signaling
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2173788).
Statements about
Downregulation of TGF-Beta Receptor Signaling
Instance Of
Biological Pathway
Negative Regulation of Transforming Growth Factor Beta Receptor Signaling Pathway
Part Of
TGF-Beta Receptor Signaling Activates SMADs
Has Part(s)
28 items
UCHL5, USP15 Deubiquitinate TGFBR1
I-SMAD Competes with SMAD2/3 for Type I Receptor (TGFBR1)
STRAP Binds Phosphorylated TGF-Beta Receptor Complex
STRAP Stabilizes Interaction of Activated TGF-Beta Receptor Complex with SMAD7
BAMBI Interferes with the Interaction of Type I Receptor with Type II Receptor
SMAD7 Recruits GADD34:PP1 to Phosphorylated TGFBR
PP1 Dephosphorylates TGFBR1
SMAD7 Binds to SMURF2
SMAD7:SMURF2 Complex Translocates to the Cytosol
SMAD7 Binds to SMURF1
SMAD7:SMURF1 Complex Binds XPO1 (CRM1)
SMAD7:SMURF1 Complex Is Exported to the Cytosol
NEDD4L Ubiquitin Ligase Binds SMAD7
SMAD7:NEDD4L Complex Translocates to the Cytosol
SMAD7:SMURF Complex Binds to Phosphorylated TGFBR1
SMURFs/NEDD4L Ubiquitinate Phosphorylated TGFBR1 and SMAD7
Degradation of TGF-Beta Receptor Complex
UCHL5 Binds SMAD7 in Complex with Ubiquitinated TGFBR1
SMURF2 Binds SMAD2
SMURF2 Ubiquitinates SMAD2
Degradation of Ubiquitinated SMAD2
SMAD3 Binds STUB1 (CHIP)
STUB1 (CHIP) Ubiquitinates SMAD3
Degradation of Ubiquitinated SMAD3
PMEPA1 Sequesters Phosphorylated SMAD2/3
PMEPA1 Sequesters Unphosphorylated SMAD2/3
MTMR4 Binds Phosphorylated SMAD2/3
MTMR4 Dephosphorylates SMAD2/3
Exact Match
https://identifiers.org/reactome:R-H ...
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