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Signaling by SCF-KIT - Ontify

Signaling by SCF-KIT

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1433557).

Statements about Signaling by SCF-KIT

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Instance Of

Biological Pathway

Part Of

Signaling by Receptor Tyrosine Kinases

Has Part(s)

32 items

Regulation of KIT Signaling

Processing of SCF Isoform 1

Dimerization of sSCF

Interaction of KIT and sSCF

Dimerization of KIT upon SCF Binding

Autophosphorylation of KIT

Direct Recruitment of PI3K to P-KIT

Synthesis of PIP3 From PIP2 by PI3K

Phosphorylation and Activation of VAV1

Interaction of Src Family Kinases with P-KIT

Phosphorylation of P-KIT on Y900 by Src Kinases

GRB2:SOS Interacts with P-KIT

SHP2 Interacts with P-KIT

Phosphorylation of SHP2 by SFKs

GRB2 Is Indirectly Recruited to P-KIT Through SHP2

Indirect Recruitment of GAB2 to P-KIT

Phosphorylation of GAB2 by SFKs

Indirect Recruitment of PI3K to KIT via P(Y)-GAB2

Activation of RAS by P-KIT Bound SOS1

Interaction of Other Tyrosine Kinases with P-KIT

Interaction of Other Adapter Proteins with P-KIT

JAK2 Binds to P-KIT

Recruitment of STATs

Phosphorylation of STATs

Dimerization of STATs

Disassociation and Translocation of STATs to the Nucleus

PTP-RO Interacts with P-C-Kit Complex

Activation of RAC1

Phosphorylation of JAK2

KIT Binds Type II TKIs

KIT Binds Type I TKIs

KIT Binds Ripretinib

Exact Match

https://identifiers.org/reactome:R-H ...