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EGFR Downregulation - Ontify

EGFR Downregulation

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-182971).

Statements about EGFR Downregulation

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Instance Of

Biological Pathway

Negative Regulation of Epidermal Growth Factor Receptor Signaling Pathway

Part Of

Signaling by EGFR

Has Part(s)

22 items

Binding of CBL to EGFR

Phosphorylation of CBL (EGFR:CBL)

CBL Binds and Ubiquitinates Phosphorylated Sprouty

Ubiquitination of Stimulated EGFR (CBL)

CBL Binds to GRB2

Localization of CBL:GRB2 to the Membrane

Phosphorylation of CBL (EGFR:GRB2:CBL)

Ubiquitination of Stimulated EGFR (CBL:GRB2)

Sprouty Lures CBL Away From EGFR

CDC42:GTP Binds CBL:Beta-Pix

Beta-Pix:CDC42:GTP Binds CBL in EGF:p-6Y-EGFR:CBL:CIN85

CIN85 Dissociates From EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85

CBL Escapes CDC42-Mediated Inhibition by Down-Regulating the Adaptor Molecule Beta-Pix

Assembly of EGFR Complex in Clathrin-Coated Vesicles

EGFR Non-Clathrin Mediated Endocytosis

CBL Ubiquitinates Sprouty

CBL-Mediated Ubiquitination of CIN85

Sprouty Sequesters CBL Away From Active EGFR

PTPN12 Dephosphorylates EGFR at Y1148 (Y1172)

EGFR Binds EPS15, EPN1, EPS15L1

EGFR Phosphorylates EPS15

PTPN3 Dephosphorylates EPS15

Exact Match

https://identifiers.org/reactome:R-H ...