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GAB1 Signalosome - Ontify

GAB1 Signalosome

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-180292).

Statements about GAB1 Signalosome

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Instance Of

Biological Pathway

Part Of

Signaling by EGFR

Has Part(s)

11 items

Binding of GRB2 to GAB1

GRB2:GAB1 Binds to Phosphorylated EGFR

PI3K Binds to EGF:EGFR:GRB2:GAB1

GAB1 Binds Phosphatidylinositol-3,4,5-Trisphosphate

GAB1 Phosphorylation by EGFR Kinase

Dephosphorylation of Gab1 by SHP2

Activation of SHP2 Through the Binding to Phospho-Gab1

Dephosphorylation of PAG by SHP2

SHP2 Dephosphorylates Tyr 992 on EGFR

Sustained Activation of SRC Kinase by SHP2

Exact Match

https://identifiers.org/reactome:R-H ...

PI3K Converts Phosphatidylinositol-4,5-Bisphosphate (PIP2) to Phosphatidylinositol-3,4,5-Trisphosphate (PIP3)