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Regulation of Necroptotic Cell Death - Ontify
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Regulation of Necroptotic Cell Death
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5675482).
Statements about
Regulation of Necroptotic Cell Death
Instance Of
Biological Pathway
Part Of
RIPK1-Mediated Regulated Necrosis
Has Part(s)
16 items
CASP8 Activity Is Inhibited
RIPK1 Is Cleaved by CASP8
RIPK3 Is Cleaved by CASP8
PELI1 Binds Activated RIPK1:RIPK3
ATP Binds MLKL
MLKL Binds IP4, IP5 and IP6
RIPK3 Binds HSP90:CDC37
MLKL Binds HSP90:CDC37
MLKL Binds FLOT1, FLOT2
MLKL Binds PDCD6IP and SDCBP
RIPK3 Binds STUB1
STUB1 Ubiquitinates RIPK3 at K55, K363
Small Molecule Inhibitor Binds RIPK1, RIPK3
Exact Match
https://identifiers.org/reactome:R-H ...
Regulation of Necroptotic Process
BIRC2/3 (cIAP1/2) Is Autoubiquitinated
O-GlcNAcylation of RIPK3 (TLR4 Signaling)
PELI1 Ubiquitinates RIPK3 at K363
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