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PINK1-PRKN Mediated Mitophagy - Ontify
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PINK1-PRKN Mediated Mitophagy
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5205685).
Statements about
PINK1-PRKN Mediated Mitophagy
Instance Of
Biological Pathway
Macroautophagy
Part Of
Mitophagy
Has Part(s)
Pink1 Is Recruited From the Cytoplasm to the Mitochondria
Pink1 Is Cleaved on Healthy Mitochondria
Uncleaved Pink1 Accumulates in Damaged Mitochondria
Pink1 Recruits Parkin to the Outer Mitochondrial Membrane.
Parkin Promotes the Ubiquitination of Mitochondrial Substrates
P62 Binds Ubiquitinated Mitochondrial Substrates
P62 Links Damaged Mitochondria to LC3
LC3 Binds the Autophagosome Membrane Atg5-Atg12 Complex
Exact Match
https://identifiers.org/reactome:R-H ...
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