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Amyloid Fiber Formation
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-977225).
Statements about
Amyloid Fiber Formation
Instance Of
Biological Pathway
Part Of
Has Part(s)
33 items
Exact Match
https://identifiers.org/reactome:R-H ...
Metabolism of Proteins
PARK2 Binds SNCAIP
Ub-SNCA Dissociates From the Conjugating Enzyme
USP9X Deubiquitinates Ub-SNCA
Serum Amyloid P-Component Forms Homopentamers
NAT8,8B Acetylate BACE1
Amyloid Fibril Formation
SIAH1, SIAH2 Bind SNCAIP
Unknown Deacetylase Deacetylates 7K-BACE1(46-501)
BACE1 Translocates From ER Lumen to Golgi Apparatus
SNCAIP Binds Alpha-Synuclein
FURIN Cleaves 7K-BACE1 to 7K-BACE1(46-501)
SIAH1, SIAH2 Ubiquitinate SNCAIP
USP9X:SNCA Dissociates
BACE1 Binds GGA1,2,3
PARK2 K63-Ubiquitinates SNCAIP
SIAH1:UBE2L6:Ubiquitin Binds SNCA
USP9X Binds Ub-SNCA
SIAH1:UBE2L6:Ubiquitin Ubiquitinates SNCA
BACE1:GGA1,2,3 Translocates From Plasma Membrane to Endosome
APP(672-713),APP(672-711) Translocate From Endosome Lumen to Extracellular Region
Gamma-Secretase Cleaves APP(672-770) to APP(672-711) and APP(672-713)
APP Translocates From Plasma Membrane to Endosome Lumen
Amyloid Fibrils Have Additional Components
ADAM10:Zn2+:TSPANs Cleaves APP(18-770)
SORL1 Binds APP(18-770)
Formation of Serum Amyloid P Decamer
BACE1(46-501) Translocates From Golgi Lumen to Plasma Membrane
BACE1 Cleaves APP(18-770) to APP(18-671) and APP(672-770)
SORL1 Transports APP(18-770) From Endosome Lumen to Golgi Lumen
CALB1 Binds 4xCa2+
Amyloid Precursor Proteins Form Ordered Fibrils
ADAM10:Zn2+ Binds TSPANs
ADAM10:Zn2+:TSPANs Translocates From ER Lumen to Plasma Membrane
Serum Amyloid P Binds DNA and Chromatin
