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Sialic Acid Metabolism - Ontify

Sialic Acid Metabolism

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-4085001).

Statements about Sialic Acid Metabolism

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Instance Of

Biological Pathway

Part Of

Synthesis of Substrates in N-Glycan Biosythesis

Has Part(s)

21 items

GNE Hydrolyzes/Epimerises UDP-GlcNAc to ManNAc and UDP

GNE Phosphorylates ManNAc to ManNAc-6-P

NANS Converts ManNAc-6-P to Neu5Ac-9-P

NANP Dephosphorylates Neu5Ac-9-P to Neu5Ac

Cytosolic Neu5Ac Translocates to Nucleus

CMAS Transfers CMP From CTP to Neu5Ac, Forming CMP-Neu5Ac

Nuclear CMP-Neu5Ac Translocates to Cytosol

SLC35A1 Exchanges CMP-Neu5Ac for CMP

ST3GAL1-6 Transfer Neu5Ac to Terminal Gal (Alpha-2,3 Link)

ST6GAL1,2 Transfer Neu5Ac to Terminal Gal (Alpha-2,6 Link)

ST6GALNAC1-6 Transfer Neu5Ac to Terminal GalNAc (Alpha-2,6 Link)

ST8SIA1-6 Transfer Neu5Ac to Terminal Neu5Ac Residues

Golgi Lumen Glycoconjugates Translocate to the Plasma Membrane

NEU3 Hydrolyzes Neu5Ac From Glycoconjugates

Cytosolic Glycoconjugates Translocate to the Lysosome

NEU1 Hydrolyses Neu5Ac From Glycoconjugates

Plasma Membrane Glycoconjugates Translocate to the Cytosol

NEU2 Hydrolyzes Neu5Ac From Glycoconjugates

NPL Cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and Pyruvate

SLC17A5 Cotransports Neu5Ac, H+ From Lysosomal Lumen to Cytosol

NEU4 Hydrolyses Neu5Ac From Glycoconjugates

Exact Match

https://identifiers.org/reactome:R-H ...